esophageal squamous cell carcinoma

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Search Results for " esophageal squamous cell carcinoma "

Compounds

Cat No.	Product Name	Synonyms	Targets
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T76717	Serplulimab	HLX 10	COX
	Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal squamous cell carcinoma.		COX
T6136	Canertinib	PD-183805,CI-1033	EGFR
	Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp...		EGFR
T38387	Compound C108		GTPase
	Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.		GTPase
T9636	Dalpiciclib	SHR-6390	CDK
	Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag...		CDK
T11691	IV-23		Others
	IV-23, a potent inhibitor of cell growth both in vitro and in vivo, effectively reduces colony formation, arrests the cell cycle at the M phase, and induces apoptosis in esophageal squamous cell carcinoma through Noxa-me...		Others
T75569	Xerophilusin B
	Xerophilusin B, isolated from Isodon xerophilus as an anticancer agent, demonstrates antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines. It induces G2/M cell cycle arrest and mediates apopt...
T74997	ERK-IN-6
	ERK-IN-6 (compound 6g) serves as a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC), inducing apoptosis through the ERK pathway. This compound has potential applications in ESCC research ...
T76997	Socazolimab
	Socazolimab (ZKAB001), an anti-PD-L1 monoclonal antibody, demonstrates enduring safety and efficacy in treating recurrent or metastatic cervical cancer. Additionally, it shows promise for treating small cell lung cancer,...
T64075	Afatinib oxalate
	Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) that acts on EGFRwt (IC50: 0.5 nM), EGFRL858R (IC50: 0.4 nM), EGFRL858R/T790M ( IC50: 10 nM) and HER2...
T72912	(R)-Afatinib	(R)-BIBW 2992
	(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM...